Cause of Alzheimer's & Breast & Prostate Cancers

Floyd’s Herbivore Feeding Deterrents (Thorns) Hypothesis on Cause of Alzheimer’s Disease And Others Diseases Paul Ewald, professor of biology and author of the book, Plague Time, The New Germ Theory of Disease, wrote, “Cancer, heart attacks, stroke, Alzheimer’s disease, and infertility are like the acts of an anonymous vandal”. In his book, Excitotoxins, The Taste that Kills, Russell L. Blaylock, M.D. notes that a multitude of seemingly unrelated diseases, such as strokes, heart attacks, arthritis, brain injury, migraine headaches, and cancer are associated with excitotoxins such as glutamate, calcium and cell death. Dr. Blaylock writes, “It appears that several of the excitotoxins, including glutamate and aspartate, work by opening calcium channels, at least on certain subtypes of receptors”. My theory or hypothesis is that the influx of calcium into the cell is not the cause of the cell death, but is in response to the threat of toxicity posed by that “anonymous vandal” that Paul Ewald writes about. This so-called “vandal” or “vandals”, in my opinion, are agents of Nature that are there to enforce Nature’s balance. Nature employes the use of phenolic compounds (I call them “thorns”) in plants as feeding deterrents to herbivores. These compounds can be grouped in three major groups: alkaloids, terpenoids, and phenolic compounds (mostly phenylpropanoids). The oxidation of these thorns creates a significant risk for our bodies by the release of excessive free radicals. Alkaloids (poisons), are synthesized principally from amino acids. These nitrogen-containing compounds protect plants from a variety of herbivorous animals, and many possess pharmacologically important activity. Our immune system’s defenses were not designed to overcome these deterrents over the long run. Consequently, as we learn to avoid them, or reduce the activity of our enzymes that oxidize them, the better off we are at consuming those plants. Dr. Blaylock lists the amino acids glutamate, aspartate and cysteine as excitotoxins that are found in nature. Phenolic compounds are widely distributed in the plant kingdom. Wheat appears to be well protected by Nature as it is quite high in alkaloids. Dr. Blaylock wrote, under the topic of, A Cascade of Destruction: The Free Radicals, that, “Once this cascade of destruction is triggered by the influx of calcium, the whole process proceeds with the explosiveness of a nuclear chain reaction”. I think that the process is initiated when our enzymes act on the inhibitors. I see this as nature’s way of enforcing its Balance of Nature by using agents such as “thorns” or inhibitors. Others have said that the redox process inside the cell is likened to a severe thunderstorm. When our bodies try to oxidize the “thorns” they become emboldened – just the opposite of what you would expect. Many of nature’s inhibitors come into the body via the diet and end up in VLDL cholesterol. The cholesterol remnants apparently containing these “thorns” are eventually transferred to LDL cholesterol. APOE is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. As herbivores, including man, attempt to metabolize these “thorns” in the lipoproteins, excessive damage to the tissues ensue. Consequently, as a process of adaptation to the “thorns” in the diet, the body has mutated and produced two additional forms or alleles of the APO-E gene. Notice the difference in the different gene products. The APO-E2 does not bind tightly to its cell surface receptor and the “thorns” have difficulty getting into the cells. However, a consequence of the APO-E2 mutation is the build-up is a terminal disease called hyperlipoproteinemia. APO-E3 is the most common form of the allele and is probably the wild-type. That leaves APO-E4. Let’s see what kind of a change it offers in response to the “toxins” in the triglyceride-rich lipoprotein constituents. APO-E4 can bind to its receptor but binds to cholesterol to a lesser degree than APO-E3. As a result, people with APO-E4 allele often have high levels of cholesterol in their blood. So, the alternate APO-E alleles E2 and E4 result in less affinity of either the receptor or cholesterol itself. This lesser affinity for cholesterol on the part of APO-E4 is largely responsible for the familial or late onset form of Alzheimer’s disease.

The Race Gene

The Race Gene Race is about a difference in degree; not a difference in kind. The difference in degree is related to the strength or activity of the enzymes or factors that control the expression of the genes that control the enzymes. Response to Stress Race is about different levels of immune response and consequentially the body’s immune response to stress. The Reason for Different Races Our bodies must adapt to the staples in our diet. This is the reason, in my opinion, for the different races. In other words, a rice-based diet will produce a different set of physical characteristics than a diet based on wheat. Melanocytes are the cells that produce melanin which is a pigment in the skin, eyes, and hair. It is not the number of melanocytes in our skin that determine whether one is lighter or darker in skin color. More importantly, it is the level of activity of the melanocytes. The enzyme, tyrosinase is responsible for the level of activity in the melanocytes. Consequently, the greater the activity of tyrosinase, the darker the skin color. Tyrosinase (monophenol monooxygenase) is an enzyme that catalyses the oxidation of phenols, and, as such, catalyzes the production of melanin and other pigments from tyrosine by oxidation. Complete lack of the enzyme produces albinism. Nature employed the use of phenolic compounds (I call them thorns) in plants as feeding deterrents to herbivores. These compounds can be grouped in three major groups: alkaloids, terpenoids, and phenolic compounds (mostly phenylpropanoids). The oxidation of these thorns creates a significant risk for our bodies by the release of free radicals. Our immune system’s defenses were not designed to overcome these deterrents. Consequently, as we learn to avoid them, or reduce the activity of the enzymes that oxidize them, the better off we are eating those plants. Now, wheat is high in alkaloids. Caucasians are more adapted to eating a wheat-based diet that other cultures or races. Therefore, the thorns in the western diet do not pose as great a risk for Caucasians as they do for African-Americans. Some races, such as the black race, more frequently express the melanin-producing genes, thereby conferring a greater concentration of skin melanin. On the other hand, other races such as the white race, less frequently express melanin-producing genes, thereby conferring a lesser amount of skin melanin. – Wikipedia. The Melanocortin-1 receptor (Mc1r) is one of the key proteins in regulating hair and skin colour. Mc1r functions at the surface of specialist pigment producing cells (called melanocytes) to regulate melanogenesis in mammals. Mutations of the Mc1r gene can either create a receptor that constantly signals, even when not stimulated, or can lower the receptor’s activity. Alleles for constitutively active Mc1r are inherited dominantly and result in a black coat colour, while alleles for dysfunctional Mc1r are recessive and result in a light coat color. Both eumelanin and pheomelanin are found in human skin and hair, but eumelanin is the most abundant melanin in humans, as well as the form most likely to be deficient in albinism. Eumelanin is found in hair and skin, and colors hair from brown to black. In humans, it is more abundant in peoples with dark skin. There are two types of eumelanin, which are distinguished from each other by their pattern of polymer bonds. The 2 types are black eumelanin and brown eumelanin. Pheomelanin is also found in hair and skin and is more abundant in fair-skinned humans. Pheomelanin also may become cancerous when exposed to the ultraviolet rays of the sun. Chemically, pheomelanin differs from eumelanin in that its oligomer structure incorporates the amino acid L-cysteine, as well as DHI (cross-linked 5,6-dihydroxyindole and DHICA 5,6-dihydroxyindole-2-carboxylic acid units. Neuromelanin is the dark pigment present in pigment bearing neurons of four deep brain nuclei: the substantia nigra (in Latin, literally “black substance”), the locus ceruleus (“blue spot”), the dorsal motor nucleus of the vagus nerve (cranial nerve X), and the median raphe nucleus of the pons. Both the substantia nigra and locus ceruleus can be easily identified grossly at the time of autopsy due to their dark pigmentation. In humans, these nuclei are not pigmented at the time of birth, but develop pigment during maturation to adulthood. Although the functional nature of neuromelanin is unknown in the brain, it may be a byproduct of the synthesis of monoamine neurotransmitters for which the pigmented neurons are the only source. The loss of pigmented neurons from specific neuclei are seen in a variety of neurodegenerative diseases. In Parkinson’s disease there is massive loss of dopamine producing pigmented neurons in the substantia nigra. A common finding in advanced Alzheimer’s disease is almost complete loss of the norepinepphine producing pigmented neurons of the locus ceruleus. Neuromelanin has been detected in primates and in carnivores such as cats and dogs. Persons with Parkinson’s disease, a disorder that affects neuromotor functioning, have been shown to have decreased neuromelanin in the substantia nigra as consequence of diminished dopamine synthesis. While no correlation between race and the level of neuromelanin in the substantia nigra has been observed, the significantly lower incidence of Parkinson’s in blacks than in whites has “prompt[ed] some to suggest that cutaneous melanin might somehow serve to protect the neuromelanin in substantia nigra from external toxins.”[9] http://www.seniorpsychiatry.com/pages/articles/lewy.html) . A decreased molecular weight or a decrease in the degree of polymerization of ocular melanin has been proposed to turn the normally anti-oxidant polymer into a pro-oxidant. In its pro-oxidant state, melanin has been suggested to be involved in the causation and progression of macular degeneration and melanoma. Melanin and human adaptation Melnocytes insert granules of melanin into specialized cellular vesicles called melanosomes. These are then transferred into the other skin cells of the human epidermis. The melanosomes in each recipient cell accumulate atop the cell nucleus, where they protect the nuclear DNA from mutations caused by the ionizing radiation of the sun’s ultraviolet rays. In 1995 a landmark study demonstrated that over 80% of humans with red hair or fair skin have a dysfunctional variant of the Mc1r gene [1] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=7581459&qu . (Check). “This discovery provoked interest in determining why there is an unusual prevelance of red hair and pale skin in some northern European populations, specifically Scotland and Ireland. The Out-of-Africa model proposes that modern humans originated in Africa and migrated north to populate Europe and Asia. It is most likely that these migrants had an active Mc1r variant and, accordingly, darker hair and skin (as displayed by indigenous Africans today).” This article from Wikipedia goes on to say that, “Concordant with the migration north, the selective pressure maintaining dark skin decreased as radiation from the sun became less intense. Thus variations in Mc1r began to appear in the human population, resulting in the paler skin and red hair of some Europeans. Studies find no evidence for positive selection driving these changes. Instead, the absence of high levels of solar radiation in northern Europe relaxed the selective pressure on active Mc1r, allowing the gene to mutate into dysfunctional variants without reproductive penalty, then propagate by genetic drift. [10].” I think otherwise. I think that a lowered immune response to stress of Northern Europeans is also reflected in a lower expression of the Mc1r gene. I think that the same stressors that are present in today’s Western diet are responsible in part or whole for the white race. See the graph listed below. Our immunity is our basic survival mechanism and over the years it has been responsibly for the survival of the species. There are numerous things in the environment and in the diet, such as bacteria, toxins and viruses that can potentially harm the body. Consequently, our bodies must be able to distinguish between “self” and “non-self”. Dr. Peter J. D’Adamo notes in his book, Live Right For Your Type, that, “Our blood type antigen is a powerful marker of self to our immune system. It is a guardian at nature’s gate, allowing access to friends and preventing entry to foes.” When man began farming and animal husbandry that brought about a dramatic change in his diet. Consumption of the agricultural diet introduced new challenges to the immune system. As such, the appearance of Blood Group A, a new ABO Blood Type, resulted from man’s new diet. Along with this new blood type came an alteration in its immune function. Instead of having antibodies against Type A antigens as the existing blood type B had, this new Type A blood had antibodies against Type B antigens, a complete opposite of Type B blood. What caused this flip in the antibodies? My take on this is that Type B people were accustomed to eating herbaceous materials such as leafy greens and full of the sugar glucose, whereas, the new farming diet incorporated more starch and protein than primarily glucose. The immune system, regardless of blood type, recognizes Type O as “self”. Some of the Type O antigens are converted to either Type A or Type B antigens resulting in Type A and Type B blood types. An enzyme exists in mineralocorticoid target tissues to prevent over stimulation by glucocorticoids. That enzyme, 11-beta hydroxysteroid dehydrogenenase type II (Protein:HSD11B2), catalyzes the deactivation of glucocorticoids to 11-dehydro metabolites. Licorice is known to be an inhibitor of this enzyme and chronic consumption can result in a condition known as pseudohyperaldosteronism. There should be a link between licorice consumption and diabetes. Sugar and salt is a leitmotif of Swedish cooking according to Mark Kurlansky, author of Salt – A World History. The Swedish word for it is sockersaltad. One of the most infamous uses of sockersaltad in Scandinavia is salt lakrits, salted licorice candy. The Dutch are also afflicted with the same craving along with other Scandinavian countries. By the consumption of sockersaltad, the glucocorticoids are or should be stimulated. This should increase the incidences of diabetes. In 1984 Borch-Johnson et al in Norway and Sweden first suggested there was an inverse correlation between type 1 and duration of breast feeding. This was not supported in 3 subsequent studies but in 1999 Elliott looked at the incidence of type 1 diabetes in children from 10 different countries which suggested that a consumption of specific milk proteins (beta-casein A and B) correlated with type 1 diabetes incidence. Different breeds of cows produce varying amounts of these proteins which produce a peptide called beta-casomorphin-7 which has immune suppressing activity. As the body gets burned by oxidizing phenols such as tyrosine, the tissues get burned. As such, the body, in a process of healing itself, cuts back on some enzyme in the pathway. As the enzyme tyrosinase becomes less effective, there is less activity in melanin. The mutation is in the receptor Mc1r. PHENOL is a poisonous caustic compound: a poisonous caustic crystalline compound obtained from coal, wood tar, or benzene, used in the manufacture of resins, dyes, and pharmaceuticals and as an antiseptic and disinfectant.

Floyd’s Herbivore Feeding Deterrents (Thorns) Hypothesis on Cause of Alzheimer’s Disease And Others Diseases

Floyd’s Herbivore Feeding Deterrents (Thorns) Hypothesis on Cause of Alzheimer’s Disease And Others Diseases Paul Ewald, professor of biology and author of the book, Plague Time, The New Germ Theory of Disease, wrote, “Cancer, heart attacks, stroke, Alzheimer’s disease, and infertility are like the acts of an anonymous vandal”. In his book, Excitotoxins, The Taste that Kills, Russell L. Blaylock, M.D. notes that a multitude of seemingly unrelated diseases, such as strokes, heart attacks, arthritis, brain injury, migraine headaches, and cancer are associated with excitotoxins such as glutamate, calcium and cell death. Dr. Blaylock writes, “It appears that several of the excitotoxins, including glutamate and aspartate, work by opening calcium channels, at least on certain subtypes of receptors”. My theory or hypothesis is that the influx of calcium into the cell is not the cause of the cell death, but is in response to the threat of toxicity posed by that “anonymous vandal” that Paul Ewald writes about. This so-called “vandal” or “vandals”, in my opinion, are agents of Nature that are there to enforce Nature’s balance. Nature employes the use of phenolic compounds (I call them “thorns”) in plants as feeding deterrents to herbivores. These compounds can be grouped in three major groups: alkaloids, terpenoids, and phenolic compounds (mostly phenylpropanoids). The oxidation of these thorns creates a significant risk for our bodies by the release of excessive free radicals. Alkaloids (poisons), are synthesized principally from amino acids. These nitrogen-containing compounds protect plants from a variety of herbivorous animals, and many possess pharmacologically important activity. Our immune system’s defenses were not designed to overcome these deterrents over the long run. Consequently, as we learn to avoid them, or reduce the activity of our enzymes that oxidize them, the better off we are at consuming those plants. Dr. Blaylock lists the amino acids glutamate, aspartate and cysteine as excitotoxins that are found in nature. Phenolic compounds are widely distributed in the plant kingdom. Wheat appears to be well protected by Nature as it is quite high in alkaloids. Dr. Blaylock wrote, under the topic of, A Cascade of Destruction: The Free Radicals, that, “Once this cascade of destruction is triggered by the influx of calcium, the whole process proceeds with the explosiveness of a nuclear chain reaction”. I think that the process is initiated when our enzymes act on the inhibitors. I see this as nature’s way of enforcing its Balance of Nature by using agents such as “thorns” or inhibitors. Others have said that the redox process inside the cell is likened to a severe thunderstorm. When our bodies try to oxidize the “thorns” they become emboldened – just the opposite of what you would expect. Many of nature’s inhibitors come into the body via the diet and end up in VLDL cholesterol. The cholesterol remnants apparently containing these “thorns” are eventually transferred to LDL cholesterol. APOE is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. As herbivores, including man, attempt to metabolize these “thorns” in the lipoproteins, excessive damage to the tissues ensue. Consequently, as a process of adaptation to the “thorns” in the diet, the body has mutated and produced two additional forms or alleles of the APO-E gene. Notice the difference in the different gene products. The APO-E2 does not bind tightly to its cell surface receptor and the “thorns” have difficulty getting into the cells. However, a consequence of the APO-E2 mutation is the build-up is a terminal disease called hyperlipoproteinemia. APO-E3 is the most common form of the allele and is probably the wild-type. That leaves APO-E4. Let’s see what kind of a change it offers in response to the “toxins” in the triglyceride-rich lipoprotein constituents. APO-E4 can bind to its receptor but binds to cholesterol to a lesser degree than APO-E3. As a result, people with APO-E4 allele often have high levels of cholesterol in their blood. So, the alternate APO-E alleles E2 and E4 result in less affinity of either the receptor or cholesterol itself. This lesser affinity for cholesterol on the part of APO-E4 is largely responsible for the familial or late onset form of Alzheimer’s disease.

Why I Will Disprove Evolution

When an Thinking Extravert is in balance, and, is straddling the opposites of Extrovert and Introvert, I find that Jung's following statement: The thinking of the extraverted type is positive, i.e., productive. It leads to the discovery of new facts or to general conceptions based on disparate empirical material. It is usually synthetic too. Even when it analyses it constructs, because it is always advancing beyond the analysis to a new combination, to a further conception which reunites the analyzed material in a different way or adds something to it. One could call this kind of judgment predicative. A characteristic feature, at any rate, is that it is never absolutely depreciative or destructive, since it always substitutes a fresh value for the one destroyed. This is because the thinking of this type is the main channel into which his vital energy flows. The steady flow of life manifests itself in his thinking, so that his thought has a progressive, creative quality.

Why Scientists Believe In Evolution

“Just as we might take Darwin as an example of the normal extraverted thinking type, the normal introverted thinking type could be represented by Kant. The one speaks with facts, and the other relies on the subjective factor. Darwin ranges over the wide field of objective reality. Kant restricts himself to a critique of knowledge. The Extraverted Thinking Type "This type will, by definition, be a man whose constant endeavor- in so far, of course, as he is a pure type - is to make all his activities dependent on intellectual conclusions, which in the last resort are always oriented by objective data, whether these be external facts or generally accepted ideas. This type of man elevates objective reality, or an objectively oriented intellectual formula, into the ruling principle not only for himself but for his whole environment. By this formula good and evil are measured, and beauty and ugliness determined. Everything that agrees with this formula is right, everything that contradicts it is wrong, and anything that passes by it indifferently is merely incidental. Because this formula seems to embody the entire meaning of life, it is made into a universal law which must be put into effect everywhere all the time, both individually and collectively. Just as the extraverted thinking type subordinates himself to this formula, so, for their own good, everybody round him must obey it too, for whoever refuses to obey it is wrong - he is resisting the universal law, and is therefore unreasonable, immoral, and without a conscience. His moral code forbids him to tolerate exceptions; his ideal must under all circumstances be realized, for in his eyes it is the purest conceivable formulation of objective reality, and therefore must also be universally valid truth, quite indispensable for the salvation of mankind.” C G Jung – Psychological Types Evolutionists, This explains why you supporters of evolution are so dogmatic: “Just as the extraverted thinking type subordinates himself to this formula, so, for their own good, everybody round him must obey it too, for whoever refuses to obey it is wrong - he is resisting the universal law, and is therefore unreasonable, immoral, and without a conscience. It is your nature.

New Paradigm For Cause of Disease

Why Do Roses Have Thorns

A New Theory of Disease

I am proposing a new theory that says that man’s chronic and acute diseases and associated inflammation are caused by a clash between the “opposites” (the opposites that are the essence of the design of nature itself) related to the design of nature and “thorns” in our diets, both of which tend to enforce the balance of nature.

Things to keep in mind:

• Nature employs the use of opposites in its design, for instance
• Even and odd numbers of things
• Male and female
• Th1 and Th2 immune responses
• Sympathetic and parasympathetic nervous system
• Double-helix

• There are two divisions in the plant kingdom
• Dicots
• Monocots

• There is balance in nature that is enforced by what I call “thorns”, as on the rose bush
• Our bodies’ enzymes are paired and have thresholds. When thresholds are exceeded they can begin to reverse the ratios

The Anti-Inflammation Zone, a book by author Dr. Barry Sears, suggests that, “The culmination of decades of research points to one thing: inflammation that you can’t feel (silent inflammation) may be the dark force responsible for many of the most feared diseases of middle and old age”. He goes one to suggest that we can alleviate this inflammation, first and foremost, by modifying what we eat.

It is not too much to suggest that this continuous level of inflammation is prima facie evidence that the immune system of the body is at war and, and, according to Dr. Sears, food is at the root of the problem. What is it about food that is causing this human misery? As our immune systems become worn down does it lead to Acquired Immune Deficiency Syndrome (AIDS)? Could HIV be a method by which one individual informs others that I have found the enemy?

In his book, Give Your Dog a Bone, Dr. Ian Billinghurst writes: “Dogs that eat grains as the major part of their diet suffer premature ageing and the early development of degenerative diseases, such as arthritis, cancer, diabetes, and other pancreatic problems. Many skin problems, allergic problems and arthritic problems respond to the withdrawal of grains from a don’s diet.”

Chemokines are essential for the inflammatory process in autoimmune diseases. The chemokine receptor-5 mediates chemotaxis by CC-chemokines and is expressed by lymphocytes with the Th1 phenotype and monocyte/macrophages. Those of us that have a 32 bp deletion in the CCR5 (CCR5-delta 32 allele) abolish receptor expression in homozygotes, while CCR5-delta carriers express less receptor than wild-type homozygotes. Zapico I, et all did a study on a total of 160 rheumatoid arthritis patients (71 and 89 with severe and non-severe phenotypes, respectively) and 500 healthy individuals from the same Caucasian population (Asturias, northern Spain) were genotyped. Carriers of the CCR5-delta 32 allele were at a significantly higher frequency (P = 0.012) in non-severe compared to severe patients (17% vs. 4%). The authors suggest that the CCR5-delta 32 polymorphism is a genetic marker related to the severity of rheumatoid arthritis.

This polymorphism is also related to the resistance to HIV-1 infection and progression towards AIDS. An elevated IgE level and increased production of Th2 cytokines are factors associated with poor prognosis in HIV infection. Consequently, both (Th1 and Th2) responses by our immune system are involved with HIV/AIDS and neither is totally effective. AIDS result from a problem of the opposites.

Understanding Nature – Matters of Consequence

Why do roses have thorns?

“The flowers have been growing thorns for millions of years. For millions of years the sheep have been eating them just the same. And is it not a matter of consequence to try to understand why the flowers go to so much trouble to grow thorns, which are never of any use to them? Is the warfare between the sheep and the flowers not important?”

From Antoine De Saint-Exupery’s book entitled, The Little Prince

translated from the French by Katherine Woods

The rose has thorns because thorns are part of nature’s way of enforcing what we call the balance of nature. Thorns on flowers allow animals to eat a little of the new growth that has immature thorns, whereas, mature thorns prevent the wild animals from destroying the rose plant itself.

If my theory is true, we should run into “thorns” in most, if not all, of nature’s plants and creatures. So, part of the balance is enforces by “thorns” and part is enforced by nature’s design.

Chinese Philosophy say that the universe is run by a single principle, the Tao, or Great Ultimate. The principle is divided into two opposite principles, or two principles, which oppose one another in their actions, yin and yang. Since no one principle dominates eternally, that means that all conditions are subject to change into their opposite.

The principles of yin and yang show how it is possible for Type B to change into Type A.

The dichotomy of nature is all around us. The human specie is composed of both male and female and our continued existence requires the mating of these two opposites. But, just as some species require sexual reproduction on the one hand, there are other species that reproduce asexually. Looking at the principles of mathematics, one notes that some numbers are even, devisable by two, whereas, others are odd and cannot be divided by two. It was recently discovered that our very DNA is composed of a double helix. The plant kingdom is divided into dicots and monocots.

Another important dichotomy for humans, at least, is the fact that the body can use both glucose oxidation and fatty acid oxidation as a source for fuel.

Dr. Barry Sears in his book, The Anti-Inflammation Zone, notes that, “…eicossanoids (eye-KAH-sa-noids) control inflammation, and that is becoming recognized as the underlying cause of many, if not all, chronic disease states that now threaten to destroy our health care system”. Many diseases such as arthritis, diabetes, cancer, heart disease, and Alzheimer’s all have a strong inflammatory component. Dr. Sears notes that if we control the inflammation, we can minimize, if not reverse, the symptoms of these chronic diseases.

If that is the case, then we can find “thorn-like” defense mechanisms and examples of “clashes of the opposites” in most, if not all, of nature’s life forms. Speaking of the latter, let’s look at blood transfusions. Doctors found out the hard way that transfusing blood from someone with Type A blood into a patient with Type B blood can cause death.

The Laws of Manu says that the pairs of opposites were ordained by the world-creator. The Ramayana says: “This world must suffer under the pairs of opposites for ever”.

In his book, The No-Grain Diet, Dr. Joseph Mercola notes, “In your body, grains, grain products, starches, and sugars have one thing in common: they rapidly turn to glucose, promote addictive eating habits, and trigger insulin release, all of which contribute to weight gain and other health problems”.

Let’s see how this causes problems. We call ourselves omnivores, meaning that we can eat anything. This says that man can exist on glucose and/or fatty acid metabolism. However, nature expects animal species in general to be either herbivores or carnivores, not both. Different, or, opposite pathways of oxidation is involved, so, it is one or the other.

Until we learned to master fire and invented agriculture, humans, by necessity, were primarily vegetarians – eating what they could chew.

Remember two things. 1) the Yin Yang principle states that one can change into the other, and, 2) the body can use glucose oxidation or fatty acid oxidation for energy.

The following shows that there is a switch (I call it a reversal of the opposites) from glucose to fatty acid metabolism as a result of too many fatty acids in the body.

“Recent findings: Recent studies have concentrated on inhibition of insulin-stimulated glucose uptake by free fatty acids as the primary cause of insulin resistance, particularly in muscle, a major site of insulin-stimulated glucose disposal”, per Internet article entitled, Over expression of muscle lipoprotein lipase and insulin sensitivity, at http://www.co-clinicalnutrition.com/pt/re/conutrition/abstract.000751.. . In general, the more excess body fat you have, the more insulin resistance you have.

According to my theory, Type II diabetes is caused by first, an overabundance of glucose brought on by consumption of grains, grain products, starches and excess sugars. Type II diabetes is a process whereby the body is in the process of switching from glucose oxidation to fatty acid oxidation for energy. Type I diabetes represent a complete switch from glucose to fatty acids as an energy source.

Let’s look at the plant kingdom opposites of monocots and dicots. The cereal grasses such as wheat, barley, oats, rye, corn, etc., are monocots. Cereals such as wheat have a unique form of defense (“thorns”) insuring the balance of nature. Two protein molecules, glutanin and gliadin, combine when chewed by animals or worked over and over as dough is kneaded in the bread-making process. Gluten forms a network that traps air bubbles, primarily from carbon dioxide, created by baking power or yeast giving bread its characteristic texture and air bubbles.

The herbivores that that live on grasses are called ruminants. They are especially equipped to handle grasses and avoid the inherent “thorns”. The ruminants have multiple chambers in their stomachs with the first part of the stomach being the rumen. According to an Internet article entitled, Do cows chew gum?, at http://www.ag.ohio-state.edu/~twig/animals/html/022397.html , “Each new mouthful of food goes directly into the rumen”. In the rumen, microbes partially digest the grasses and then the ruminant regurgitates and chews the cud. Consequently, the ruminants avoid masticating the glutanin and gliadin protein molecules that in turn activate gluten.

Scientists say that blood Group A resulted from the introduction of the agricultural diet. It seems to me that such a low-glucose/high starch (fatty acid) diet, caused the reversal of blood Group B to the opposite blood Group A.

For humans, gluten appears to be the ultimate Trojan horse. The “thorns” – the ability to make dough rise, (gluten) in wheat and other cereals is the special attribute that humans value. In fact, we believe that the more gluten in the flour the better the flour.

“Dairy products, wheat and its close relatives, oats, barley, and rye, have proved to be a major problem in the diets of our patients. There are many possible reasons for cereal grains to become pathogenic”, according to the Celiac.com Internet article, Arthritis and Celiac Disease, posted at http://www.celiac.com/st_prod.html?p_prodid=87 . This article suggests that hypersensitivity mechanisms triggered by grain proteins and this is the likely cause of the illnesses related to the consumption of cereal grains.

So, this is key - the human body which lacks the multiple chambers in the stomach, and, does not chew the cud, becomes hypersensitivity to the presence of the “thorns” found in cereal grains. Let’s see some of what happens.

A wheat gluten mechanism has been studies in rheumatoid arthritis patients. The clinical observation is that wheat ingestion is followed within hours by increased joint swelling and pain. Dr. Barry Sears in his book, The Anti-Inflammation Zone, notes that, “…eicosanoids (eye-KAH-sa-noids) control inflammation, and that is becoming recognized as the underlying cause of many, if not all, chronic disease states that now threaten to destroy our health care system”.

A pair of opposites is evident in the eicosanoids in the body’s cells. One the one hand, we have the pro-inflammatory ones that promote inflammation and tissue destruction, and, on the other hand, we have the anti-inflammatory ones that stop inflammation and promote healing. Dr. Sears notes that if these opposites are out of balance, for instance, if the pro-inflammatory eicosanoids aren’t called back to the barracks, inflammation runs amok and your immune system starts attacking your body. He suggests that we can move from pro-inflammatory eicosanoids toward anti-inflammatory eicosanoids first and foremost by modifying …”what you eat”.

There is another pair of opposites in human anatomy called secretors and non-secretors.

Secretors reverse their Lewis antigens from a+b- to a-b+. Secretors, between 80 and 85 percent of the population, also secrete their blood type antigen in their bodily secretions such as saliva and semen.

So, how does the human body respond to an enemy that it can hardly identify? The answer is that it does what it can to keep the varmint out.

Celiac Disease

Celiac disease is a severe intestinal intolerance to wheat or gluten. People whose body can recognize gluten as the enemy require an absolute wheat/gluten restriction for their entire lives. Their immune systems will go so far as complete destruction the villi, the tiny, fingerlike protrusions, that line the small intestines in an effort to prevent entry of gluten into their bodies. Villi normally allow nutrients from food to be absorbed into the bloodstream. People of blood Type O, having antibodies against both Type A and Type B antigens seem better at identifying gluten containing cereals as the enemy.

The human immune system, having identified the culprit, considers this valuable information and passes it along to offspring. Consequently, celiac disease is a genetic disease. It is also considered an autoimmune disease because the immune system seems to be attacking itself, when, in fact it is attacking the Trojan horse gluten which is the cause of the problem. I think that this is the nature of many, if not all, autoimmune diseases. Autoimmune diseases should be called idiopathic immune diseases.

Dr. Joseph Mercola, author of The No-Grain Diet, says, “I am convinced all blood Type O individuals should not eat wheat. I suspect that most of us would benefit from a similar restriction”.

In a study published in the Lancet (July 17, 1999;354:222-223), researchers in Rome, Italy examined 52 patients with idiopathic cardiomyopathy (heart disease with no known cause) for celiac disease. Three of them had celiac disease, suggesting that prevalence of celiac disease in idiopathic cardiomyopathy patients is increased.

According recent research published in the journal Hematology-Oncology Clinics of North America, “Celiac disease is a risk factor for the development of both adenocarcinoma and T-cell lymphoma of the small intestine. The development of lymphoma accounts for the majority of the increased mortality in celiac disease,” according to P.H.R. Green and al, Columbia University College of Physicians & Surgeons.

It seems to me that in Small Intestinal T-cell Lymphoma the body tries to adapt to the gluten diet. Laboratory diagnosis shows the following partial

morphology.

• There is full thickness replacement of the wall of the intestine by large highly pleomorphic lymphoid cells
• The adjacent mucosa often shows vilous atrophy. There are large number of intra-epithelial lymphocytes that may show cytological atypia

The tumor cells have an abnormal peripheral T-cell phenotype. It is reported that in some cases there is absence of CD4 and CD8 expression.

Again, as the body’s immune system tries to protect us from gluten, it ends up on the short end of the stick - The development of lymphoma accounts for the majority of the increased mortality in celiac disease.

Some people react to gluten in the diet with eating disorders. Anorexia and bulimia are linked to celiac disease and therefore gluten intolerance. Many celiac patients say that they avoid eating for long periods to avoid the inevitable uncomfortable (and even painful) symptoms in the stomach. Many celiacs also automatically vomit after meals in which they have consumed gluten-containing foods or anytime their symptoms are nauseating or painful.

Cystic fibrosis is the most frequent lethal genetic disease of childhood. It affects the lungs, digestive system, sweat glands, and male fertility. CF affects approximately 30,000 children and young adults in the United States and about 3,000 infants are born with CF every year. CF is caused by a deletion (delta-F508) in the so-called CF gene.

The normal role of the CFTR protein is to allow chloride ions to exit the mucus-producing cells. When the chloride ions leave these cells, water follows, thinning the mucus. Two hallmarks of the disease are the secretion of thick mucus and dead white blood cells.

I am speculating that CF is a mutation in the gene due to the presence of gluten in the diet for increased mucus protection.

The defect causing CF cause the lungs and pancreas to secrete thick mucus, blocking passageways and preventing proper function, according to researchers. This action also prevents the digestion of cereals and it protects the intestinal tract from the ravages of gluten. The major contents of mucus are 1) bacteria, 2) the regular contents of mucus, and 3) dead white blood cells, which are present in CF’ers in a concentration about 1,000 larger than in normal people. To me, this indicates that the white blood cells in the CF patient tangle with the “thorns” of cereals.

According to Dr. Peter J. D’Adamo in his book, Live Right For Your Type, non-secretors are more prone to generalized inflammation than secretors, although their immune responses are not as efficient. Evidently, secretors have adapted or otherwise found a way to reduce the inflammatory response generated by “thorns” not only in cereals, but also in other foods such as legumes and beans. It appears as though IgE-mediated food allergy is somewhat avoided by secretors. And, this is not the case for the non-secretors.

The “thorns” in cereals are opposite to what the immune system of human can handle. Our immune system is used to presenting one antigen to helper cells ______________ for help in fighting the enemy. Gluten is composed of two proteins and I assume two antigens. Consequently, our immune system can only attack one-half of the gluten problem.

According to a PubMed article entitled, Different profiles of wheat antigens are recognized by patients suffering from celiac disease and IgE-mediated food allergy, located at http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16…, “Dietary intake of wheat can cause tow distinct immunologically mediated diseases with severe gastrointestinal manifestations, celiac disease (CD) and IgE-mediated food allergy. The pathomechanisms underlying these diseases are different…”. The authors conclude that, “This study thus demonstrates that wheat contains antigens/epitopes which are preferentially recognized by CD patients, whereas others elicit IgE-mediated food allergy.

Chemokines are critical for the inflammatory process in autoimmune diseases such as rheumatoid arthritis (RA). The chemokine receptor-5 (CCR5) mediates chemotaxis by CC-chemokines and is expressed by lymphocytes with the Th1 phenotype and monocyte/macrophages. A 32 bp deletion in the CCR5 (CCR5-delta 32 allele) abolishes receptor expression in homozygotes, while CCR5-delta 32 carriers would express less receptor than wild-type homozygotes.

Non-secretors are more prone to both type I and type 2 diabetes than the secretors are.

Non-secretors have a higher rate of alcoholism over secretors. They are also the group that moderate alcohol intake is most likely to have protective effect.

Non-secretors have an increased prevalence of a variety of so-called autoimmune diseases such as ankylosing spondylitis, reactive arthritis, psoriatic arthropathy, Graves disease, Sjogren’s syndrome, multiple sclerosis, etc.

The human major histocompatibility complex (MHC) maps to the short arm of chromosome 6 and contains the polymorphic HLA genes. These genes are fundamental for the acquired immune response. HLA class I products bind to endogenous antigenic epitopes and present them to CD8+ CTLs, while HLA class II products present exogenous antigenic peptides to CD4+ helper T-cells.

“Numerous diseases are associated with the HLA loci and a number of them are autoimmune diseases. HLA-B27 is associated with the spondyloarthropathies (SpA), including ankylosing spondylitis (AS), Reiter’s syndrome, reactive arthritis, inflammatory bowel disease and psoriatic spondylitis. HLA-B27 is highly associated with AS (98% is positive), whereas the prevalence in other forms of SpA varies between 50-80%. The B27-antigen is present in 8-20% of healthy Caucasians, depending on their geographic distribution, with the highest prevalence being in the northern zones

HIV/AIDS

There are two kinds of helper T cells.

• Th1 – These participate in cell-mediated immunity. They are essential for controlling such intracellular pathogens as viruses and certain bacteria, e.g., Listeria and Mycobacterium tuberculosis (the bacillus that causes tb)
• Th2 – These provide help for B cells and, in so doing, are essential for antibody-mediated immunity. Antibodies are needed to control extra cellular pathogens (which – unlike intracellular parasites – are exposed to antibodies in blood and other body fluids).

Like all T cells, Th cells arise in the thymus.

• When they acquire CD4, they are called pre-Th cells
• When they are presented with both
• An antigen and
• Appropriate cytokines, they begin to proliferate and become activated

It is the nature of the stimulation that determines which path they enter: the path leading to Th1 cells or the path leading to Th2 cells.

The antigen-presenting cells (APCs) are called dendritic cells (DC). They

• Ingest antigen by phagocytosis or pinocytosis
• Degrade it, and
• Present fragments of the antigen at their surface
• Secrete cytokines

There are two kinds of dendritic cell

• DC1 – these are descended from monocytes
• DC2 – these appear to be derived from lymphocytes

Th1 Cells

Th1 cells are produced when DC1-type dendritic cells and pre-Th cells form an immunological synapse in which the dendritic cell

• Presents antigen to the T cell’s receptor for antigen (TCR);
• Secretes interleukin 12 (IL-12)

The paracine stimulation by IL-12 activates (through JAK-STAT pathways) the Th1 cells to secrete their own lymphokines:

• Tumor-necrosis factor-beta (TNF-B) (also known as lymphotoxin) and
• Interferon-gamma (IFN-y)

These

• Stimulate macrophages to kill the bacteria they have engulfed;
• Recruit other leukocytes to the site producing inflammation

Th2 Cells

Th2 cells are produced when DC2-type dendritic cells present antigen to the T cell’s receptor for antigen (TCR) and, presumably, one or more paracrine stimulants. The identity of the cytokine(s) is still uncertain

The major lymphokines secreted by Th2 cells are

• Interleukin 4 (IL-4). This
• Stimulates class-switching in B cells and promotes their synthesis of IgE antibodies
• Acts as a positive-feedback device promoting more pre-Th cells to enter the Th2 pathway
• Blocks the IFN-y receptors from entering the immunological synapse on pre-Th cells thus inhibiting them from entering the Th1 path
• Interleukin 5 (IL-5). Attracts and activates eosinophils
• Interleukin 10 (IL-10). Inhibits IL-12 production by DCs thus inhibiting pre-Th cells from entering the Th1 pathway
• Interleukin 13 (IL-13). This also promotes the synthesis of IgE antibodies

The following info was taken from the Internet article entitled Helper T Cells located at http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/T/Th1_Th2.html .

A Th1 response inhibits the Th2 path in two ways:

IFN-y and IL-12 inhibit the formation of Th2 cells;

Ifn-y also inhibits class switching in B cells

A Th2 response inhibits the Th1 path:

IL-4 and IL-10 suppress Th1 formation

Negative feedback of Th1 and Th2 cell formation

There is evidence that late in the immune response, negative feedback mechanisms come into play to dampen the response.

IL-4 kills the precursors of the DC2 cells (by apoptosis) thus inhibiting the Th2 path and further production of IL-4

IFN-y may eventually turn off the Th1 response that produced it.

Th1 and Th2 cells have different chemokine receptors.

Chemokines are cytokines that are chemotactic for (attract) leukocytes. Because they are chemotactic cytokines, chemokines are designated by the initials CC.

Chemokines bind to receptors on the responding leukocyte. The receptors are transmembrane proteins with the chemokine-binding site exposed at the surface of the plasma membrane. Chemokine receptors are designated CCR.

Th1 cells and Th2 cells have opposite functions.

Th1 cells express the chemokine receptor CCR5 (but not CCR3).

Th2 cells express the chemokine receptor CCR3 (but not CCR5).

CCR3

One chemokine that binds to CCR3 is called eotaxin. It is secreted by epithelial cells and phagocytic cells in regions where allergic reactions are occurring.

CCR3 is found on

· Th2 cells

· Eosinophils

· Basophils

All cells implicated in allergic responses (e.g., asthma).

CCR5

CCR5 is found on

• Th1 cells, especially those in the lymphoid tissue of the intestine
• Macrophages

CCR5 also acts – along with the CD4 molecule – as a co-receptor for HIV-l, the retrovirus that causes AIDS. This fact may explain

· Why destruction of the lymphoid tissue of the intestine occurs soon after HIV infection;

· Why certain HIV-infected men

· With inherited mutations in CCR5 or

· Who produce high levels of the natural ligand for CCR5 (a chemokine designated CCL3L1). CCL3L1 presumably competes with HIV for access to CCR5.

· Can tolerate their infection for long periods without progressing to a full-blown case of AIDS;

· The collapse of cell-mediated immunity in the late stages of AIDS.

End

CCR5 cytokine levels correlate with disease activity of Wegener’s Granulomatosis patients.

Chemokines are critical for the inflammatory process in autoimmune diseases such as rheumatoid arthritis (RA). The chemokine receptor-5 (CCR5) mediates chemotaxis by CC-chemokines and is expressed by lymphocytes with the Th1 phenotype and monocyte/macrophages. A 32 bp deletion in the CCR5 (CCR5-delta 32 allele) abolishes receptor expression in homozygotes, while CCR5-delta 32 carriers would express less receptor than wild-type homozygotes. This polymorphism is related to the resistance to HIV-1 infection and progression towards AIDS. We hypothesized that the CCR5-delta 32 allele may modulate the severity of disease in RA. A total of 160 RA-patients (71 and 89 with severe and non-severe phenotypes, respectively) and 500 healthy individuals from the same Caucasian population (Asturias, northern Spain) were genotyped. Carriers of the CCR5-delta 32 allele were at a significantly higher frequency (P – 0.012) in non-severe compared to severe patients (17$ vs. 4%). Our results suggest that the CCR5-delta 32 polymorphism is a genetic marker related to the severity of RA.

As stated earlier wheat contains antigens/epitopes, which are preferentially recognized by CD patients, whereas others elicit IgE-mediated food allergy. In other words, the human immune system is incapable of recognizing the “thorns” in the gluten proteins. Also, as a problem of the opposites, the human immune system is incapable of defending against the “thorns” in cereals.

“An elevated IgE level and increased production of T(H2) cytokines are factors associated with poor prognosis in HIV infection”, per PubMed article entitled, Cytokine profile of a long-term pediatric HIV survivor with hyper-IgE syndrome and a normal CD4 T-cell count, at http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=20.. .

I have read that the DNA double-helix of monocots is different from the one of humans and dicots. Apparently, one strain of the DNA of monocots is the same as ours and one is different. Gluten and other monocots present “thorns” that our immune system cannot handle and are, therefore, likely responsible.

HIV Is Another Way of Saying Eurica

Breastfeeding passes on crucial antibodies to infants that protect them against allergies. It is reported that half of the children with HIV in sub-Saharan Africa today were infected with the disease through breast milk from their HIV-positive mothers. Could the transmission of HIV be a way of one human informing another that the enemy has been identified and what it looks like?

Could HIV/Aids result from humans finally becoming able to recognize the villain in cereal grains and stimulating the body to begin a war against an enemy (gluten) that it cannot win? Or, is it that late in the immune response against HIV, a negative feedback mechanisms come into play to dampen a Th response?

It is estimated that 59% of LGBT youth smoke, whereas the prevalence rate in the general youth population is only 37%.

It is reported that cocaine and amphetamines are so addictive because they increase dopamine. However, Dr. Jack B. Stein, Ph.D., deputy director, Office of Science Policy and Communications, National Institute on Drug Abuse (NIDA) has demonstrated changes in the brain with photographic evidence from PET-scans of methamphetamine abusers that show a depletion of dopamine. (L.A. Gay & Lesbian Center – Report From The Third Lesbian, Gay, Bisexual and Transgender Health Roundtable – June 6 – 7, 2002). Maybe, drugs such as cocaine, crack cocaine, crystal, Ecstasy and other club drugs should be classified as depressants instead of stimulants.

Of all stimulants, users of crystal methamphetamine take fewer years to enter treatment; the average use is 3.7 years. It is reported that 91% of crystal users are HIV-infected, whereas only some 33% of users of other stimulants are infected. Sexual activity occurs in 91% of crystal users and in 56% of other stimulant users. Crystal users are almost three times more likely to consider recent sexual behaviors as compulsive (64%) compared to other stimulant users (22%), and to have more sexual partners in the last 30 days (crystal users, 5.5 partners; users of other stimulants, 2.1 partners). Crystal users have more than three times the number of sexual partners (19) in the previous six months than other stimulant users (6). Users of crystal describe it as pushing sexual extremes, pushing sexual intensity, prolonging sexuality and increasing thoughts about sex.

L.A. Gay & Lesbian Center – Report From The Third Lesbian, Gay, Bisexual and Transgender Health Roundtable – June 6 – 7, 2002.

Depression and chronic hopelessness is frequently seen with those in long-term substance abuse treatment facilities and those living with HIV, as well as their care providers. By 2010 depression will be the number one mental health diagnosis for LGBT people.

Gay men are more likely to be extroverted, use alcohol, and, be single or in short-term relationships according to Internet article Introduction to Gay Male Domestic Violence at http://www.psychpage.com/gay/library/gay_lesbian_violence/dv_gay…

Vioxx

Anti-inflammatory drugs work to stop the production or overproduction of pro-inflammatory eicosanoids.

ADHD

The hyperactivity in ADHD could result from over stimulation of the sympathetic branch of the nervous system by “thorns” in the diet. The sympathetic nervous system is designed to take action on a moment’s notice. It does not wait around for thinking. It is more reactive.

Carl Jung wrote about the opposite functions of Thinking versus Sensing. When the body is constantly in a reaction mode the senses become the dominant function.

The body responds to these “thorns” by activating the excitatory neurotransmitter dopamine.

“When your body is in a constant state of silent inflammation, it reacts by having your adrenal glands pump out high amounts of cortisol, the primary anti-inflammatory hormone you have to shut down excess inflammation”, per Dr. Sears in his book, The Anti-Inflammation Zone.

Over time, the body adapts by gearing up for an intense inflammatory response and this propensity is passed on to our offspring for their benefit.

Marti Olsen Laney, Psy.D., author of the book, The Introvert Advantage, notes that, “Not only does introverts’ and extroverts’ blood travel on separate pathways, each pathway requires a different neurotransmitter”. On their more dominant pathway, Extroverts use the neurotransmitter activated by dopamine. On their dominant pathway, Introverts use the opposite neurotransmitter activated by acetylcholine. According to Dr. Laney, acetylcholine “affects attention and learning (especially perceptual learning, influences the ability to sustain a calm, alert feeling and to utilize long-term memory, and activates voluntary movement. It stimulates a good feeling when thinking and feeling.” Acetylcholine is quite involved in the brain. It is associated with sleep and dream states and a deficiency of acetylcholine is linked to Alzheimer’s disease. Estrogen is supposed to prevent a decline in this neurotransmitter.

The neurotransmitter dopamine is most closely identified with movement, alert states, attention and learning. The level of dopamine in the body is increased by the release of adrenaline.

It is reported that cocaine and amphetamines are so addictive because they increase dopamine. However, Dr. Jack B. Stein, Ph.D., deputy director, Office of Science Policy and Communications, National Institute on Drug Abuse (NIDA) has demonstrated changes in the brain with photographic evidence from PET-scans of methamphetamine abusers that show a depletion of dopamine. (L.A. Gay & Lesbian Center – Report From The Third Lesbian, Gay, Bisexual and Transgender Health Roundtable – June 6 – 7, 2002). Maybe, drugs such as cocaine, crack cocaine, crystal, Ecstasy and other club drugs should be classified as depressants instead of stimulants.

Over stimulation of dopamine eventually causes lower sensitivity.

Extroverts are more sensory orientated. The area of the brain where their blood flows is where visual, auditory, touch, and taste (excluding smell) occur.

Dr. Laney notes that Introverts are highly sensitive to dopamine and that too much will leave them over stimulated. Since our kids are hyper I would assume that they of usually of the Introvert persuasion.

ALS

Acetylcholine paralyzes us (disengages voluntary movement) when REM sleep is switched on initiating dreaming. Dr. Laney quotes Ronald Kotulak who writes in his book Inside the Brain, “Acetylcholine is the oil that makes the memory machine function. When it dries up the machine freezes.”

One patient with ALS indicated that he was allergic to MSG and that whenever he would drink beer his ALS symptoms would worsen. MSG and beer come from cereals.

According to an Internet article entitled, “My Ideas As To The Cause Of ALS” at http://members.aol.com/pganzel/my.html , Peter Ganzel, an ALS patient, interviewed others afflicted with ALS along with his own insights and created a profile of a typical ALS patient. Three things on the profile are:

Athletic

Heavy dairy consumption

Tremendous stress

It appears to me that there is an attempted switch of the primary neurotransmitters in the brain – from acetylcholine to dopamine. Up until around age 2, the dominant neurotransmitter in the brain is dopamine then it switches to acetylcholine. The heavy dairy consumption may cause the body to attempt to revert back to the dopamine pathway.

Introvert vs. Extravert

Dr. Laney believes that the basic foundations Introversion and Extroversion are determined by whichever branch of the autonomic nervous system is primarily activated. Parasympathetic activation equates to Introversion and sympathetic activation equals Extroversion.

I think that the orientation of the Th1 and Th2 response may be the determining factor as to which neurotransmitter and particular branch of the nervous system is activated. Th1 is focused on the internal functioning of the cells, whereas, Th2 is focused on the external concerns of the cells.

Gay men are more likely to be extroverted, use alcohol, and, be single or in short-term relationships according to Internet article Introduction to Gay Male Domestic Violence at http://www.psychpage.com/gay/library/gay_lesbian_violence/dv_gay…

Our children’s bodies run primarily on an Extraverted basis until they are around two years old.

Multiple Sclerosis

It is reported that in individuals with MS, there is evidence that specific white blood cells are primed to recognize and launch attacks against apparently normal components of the nervous system.

The body attacks itself through a process called apoptosis – the necessary death of cells. This is a form of cell death that is necessary to make way for new cells and to remove cells whose DNA has been damaged to the point at which cancerous change is liable to occur.

The fact that it has become clear since the mid-1990’s that individuals without MS also have T cells that react against myelin is additional evidence that MS could be a reaction of the body against the amino acid glutamic acid.

Health Disparities

Approximately one in every 25 Americans of northern-European descent is a carrier of the mutated CF gene, but, only one in 17,000 African Americans and one in 30,000 Asian Americans are carriers.

Natural selection would dictate that such harmful consequences of a mutation would dictate its demise fairly soon. Some evolutionists say that such a high mortality of CF would quickly lead to loss of the mutated gene from the population. However, natural selection is not at play here.

Too Much – The Great Tsunami

Since the advent of farming, the agricultural diet has provided too much energy to the body. Consequently, enzymes have had to tone-down or decrease in activity. Caucasians exhibit this in the enzyme activities that provide skin color, eye color and hair. The ability to taste food has decreased creating a need for MSG. Many people have a reduced ability to recognize several nutrients such as PROP.

G6PD in some 400 million people reflect a decrease in these people’s ability to use energy.

Cystic Fibrosis causes a decrease in the ability to thin mucus.

Why Do Roses Have Thorns

A New Theory of Disease

My Theory In a Nutshell 12/14/05

An important dichotomy for humans is the fact that the body can use either glucose oxidation or fatty acid oxidation as a source for fuel. In the presence of glucose in the diet from vegetables and fruits, as designed, the body works wonderfully. The lack of sufficient glucose in the diet triggers the body to fall back, default, or, in other words, go to the opposite energy source – fatty acids, for survival. However, this energy pathway results in destructive metabolism, but, helps insure the continuation of the specie.

Part of our problem is that there are “thorns”(a euphemism for lectins) in wheat and other seeds, and, vegetables for that matter, that activate our immune system as these “thorns” represent a danger to our well-being. The cereals utilize gluten as their “thorns”. Cereals such as wheat have a unique form of defense (“thorns”) insuring the balance of nature. Two protein molecules, glutanin and gliadin, combine when chewed by animals or worked over and over as dough is kneaded in the bread-making process. For the cereals, this is a great secret weapon. Most of our immune systems cannot detect gluten as being an enemy. Then, once it is targeted by the immune system, as in celiac disease, it is recognized as the formidable foe that it is. Gluten represents an opposite as to what our immune system can defend us against. In my opinion, that is why grass herbivores have multiple chambers in the stomach and chew the cud or masticate the grains after the “thorns” have been disabled or neutralized by microorganisms in the rumen.

Gluten forms a network that traps air bubbles, primarily from carbon dioxide, created by baking power or yeast giving bread its characteristic texture and air bubbles. For humans, gluten appears to be the ultimate Trojan horse. The “thorns” – the ability to make dough rise, (gluten) in wheat and other cereals is the special attribute of wheat that humans value in bread making. In fact, we believe that the more gluten in the flour the better the flour.

As the ratio of starch to glucose increase, the more there is of a tendency to switch or migrate to the opposite form of energy. The complete migration to fatty acids oxidation is reflected in Type 1 diabetes. According to Diabetes – UK, prior to the advent of insulin, Type 1 diabetes were placed on a milk diet, which allowed them to live up to two years. Type 2 diabetes, in my opinion, represents a “switch to the opposite” in progress. As the body migrates from glucose to fatty acids, the body’s cells become less sensitive to insulin. In fact, the beta cells of the pancreas switch function from the production of insulin to the production of amylin as first noted by Eugene L. Opie and Leonid Sobelev somewhere around 1902. According to the book, The Diabetic Male’s Essential Guide to Living Well, by Joseph Juliano, M.D., Opie and Sobelev identified that change in function of the beta cells resulted in diabetes.

In order to fight cancer, one needs to determine just what cancer is. Tumors represent a way of altering or adapting the functions of the body’s organs and tissues to a different environment. Cancer results when the body cannot control the tumor or adaptation process, in my opinion, sometimes due to the influence of peptides from gluten.

As the ratio of starch to glucose increases, there is increased pressure on the body to make adjustments. Linus Pauling, the chemist and biologist that is among the few people awarded two Nobel Prizes, advocated that it was the lack of vitamin C in the diet that caused cancer. He was partially correct. It is the lack of a glucose-providing, vitamin C providing diet that naturally comes with the consumption of fruits and vegetables that cause cancer. Keep in mind, humans do not manufacture vitamin C, therefore, it must come from the diet. This vegetarian diet is tuned to provide all of the requisite nutrients in their correct ratios from a vegetarian diet. For instance, prior to the advent of farming, the Neolithic man spent most of his days eating herbaceous materials. Of course, there were some editable seeds during the seed-bearing part of the year. It is easy to surmise that they didn’t get a lot of energy from such a diet. However, that was the status quo until the advent of farming and domestication of animals. Subsequently, man body has had to adjust to excess nutrients in the diet. For example, the body needs iron for hemoglobin. The body absorbs 10 times more iron from meat than it does from fruits and vegetables. Consequently, the body needs to make adaptations. In many cases, these changes are made by mutations of genes and many of these mutations result in tumors, some of which go out of control and form cancer. This is to be expected when the “opposites of the body” are out of control.

Consumption of grains and seeds cause a shift in the opposites of cholesterol. HDL decreases and LDL increases. According to LipoScience, Inc., it is the amount and the size of the particles in LDL cholesterol and triglycerides that is indicative of coronary heart disease risks. Let’s observe two pairs of opposites in play – size and quantity.

Large size particles, whether in HDL, LDL and/or triglycerides represent a lower CHD risk. On the other hand, small size particles in HDL, LDL, and/or triglycerides (VLDL) are indicative of greater risks. As far as quantity of particles is concerned, a smaller number of them equals smaller risk, and, more of them increases the risk of CHD. Although these particles are too small to be analyzed these particles can be expected to contain peptides of gluten and other plant lectins (“thorns). The LDL is protective in surrounding the “bad guys” in fat, thereby isolating them from necessary water. Consequently, considering the circumstances causing “thorns” in the triglycerides, hypercholesterolemia, as provided by the immune system, is protective.

As indicated earlier, the “thorns” in cereals represent an enemy that our immune system was not designed to handle. Arthritis and, eventually, cancer, Alzheimer’s and AIDS are likely to result.

Niacin (nicotinic acid) has the ability to reduce small LDL particles by some 30 to 50 percent according to LipoScience, Inc. Is this the reason that people smoke, especially after eating? I think that the answer is definitely yes.

Drugs such as Vioxx that affect the COX enzymes have the effect of disarming the immune system response, and, in essence, leaving the body unprotected against the “thorns” of gluten and other seeds.

Pythagoras, the Greek philosopher and mathematician, said, “Don’t eat fava beans”. Fava beans were the sole representative of beandom in Europe until the discovery of America. Pythagoras did not say why one should not eat such beans, however, he was aware that there were “thorns” in those beans that could adversely affect the human body.

Favism or Glucose-6-phosphate dehydrogenase deficiency (G6PD) is an inherited X-linked recessive trait (Lamb) that affects over 400 million people throughout the world, and, it is the most common enzymopathy in the world (King and Stansfield). To put it another way, G6PD deficiency is the most common enzyme deficiency in the world.

Why Do Roses Have Thorns

A New Theory of Disease

I am proposing a new theory that says that man’s chronic and acute diseases and associated inflammation are caused by a clash between the “opposites” (the opposites that are the essence of the design of nature itself) related to the design of nature and “thorns” in our diets, both of which tend to enforce the balance of nature.

Things to keep in mind:

• Nature employs the use of opposites in its design, for instance
• Even and odd numbers of things
• Male and female
• Th1 and Th2 immune responses
• Sympathetic and parasympathetic nervous system
• Double-helix

• There are two divisions in the plant kingdom
• Dicots
• Monocots

• There is balance in nature that is enforced by what I call “thorns”, as on the rose bush
• Our bodies’ enzymes are paired and have thresholds. When thresholds are exceeded they can begin to reverse the ratios

The Anti-Inflammation Zone, a book by author Dr. Barry Sears, suggests that, “The culmination of decades of research points to one thing: inflammation that you can’t feel (silent inflammation) may be the dark force responsible for many of the most feared diseases of middle and old age”. He goes one to suggest that we can alleviate this inflammation, first and foremost, by modifying what we eat.

It is not too much to suggest that this continuous level of inflammation is prima facie evidence that the immune system of the body is at war and, and, according to Dr. Sears, food is at the root of the problem. What is it about food that is causing this human misery? As our immune systems become worn down does it lead to Acquired Immune Deficiency Syndrome (AIDS)? Could HIV be a method by which one individual informs others that I have found the enemy?

In his book, Give Your Dog a Bone, Dr. Ian Billinghurst writes: “Dogs that eat grains as the major part of their diet suffer premature ageing and the early development of degenerative diseases, such as arthritis, cancer, diabetes, and other pancreatic problems. Many skin problems, allergic problems and arthritic problems respond to the withdrawal of grains from a don’s diet.”

Chemokines are essential for the inflammatory process in autoimmune diseases. The chemokine receptor-5 mediates chemotaxis by CC-chemokines and is expressed by lymphocytes with the Th1 phenotype and monocyte/macrophages. Those of us that have a 32 bp deletion in the CCR5 (CCR5-delta 32 allele) abolish receptor expression in homozygotes, while CCR5-delta carriers express less receptor than wild-type homozygotes. Zapico I, et all did a study on a total of 160 rheumatoid arthritis patients (71 and 89 with severe and non-severe phenotypes, respectively) and 500 healthy individuals from the same Caucasian population (Asturias, northern Spain) were genotyped. Carriers of the CCR5-delta 32 allele were at a significantly higher frequency (P = 0.012) in non-severe compared to severe patients (17% vs. 4%). The authors suggest that the CCR5-delta 32 polymorphism is a genetic marker related to the severity of rheumatoid arthritis.

This polymorphism is also related to the resistance to HIV-1 infection and progression towards AIDS. An elevated IgE level and increased production of Th2 cytokines are factors associated with poor prognosis in HIV infection. Consequently, both (Th1 and Th2) responses by our immune system are involved with HIV/AIDS and neither is totally effective. AIDS result from a problem of the opposites.

Understanding Nature – Matters of Consequence

Why do roses have thorns?

“The flowers have been growing thorns for millions of years. For millions of years the sheep have been eating them just the same. And is it not a matter of consequence to try to understand why the flowers go to so much trouble to grow thorns, which are never of any use to them? Is the warfare between the sheep and the flowers not important?”

From Antoine De Saint-Exupery’s book entitled, The Little Prince

translated from the French by Katherine Woods

The rose has thorns because thorns are part of nature’s way of enforcing what we call the balance of nature. Thorns on flowers allow animals to eat a little of the new growth that has immature thorns, whereas, mature thorns prevent the wild animals from destroying the rose plant itself.

If my theory is true, we should run into “thorns” in most, if not all, of nature’s plants and creatures. So, part of the balance is enforces by “thorns” and part is enforced by nature’s design.

Chinese Philosophy say that the universe is run by a single principle, the Tao, or Great Ultimate. The principle is divided into two opposite principles, or two principles, which oppose one another in their actions, yin and yang. Since no one principle dominates eternally, that means that all conditions are subject to change into their opposite.

The principles of yin and yang show how it is possible for Type B to change into Type A.

The dichotomy of nature is all around us. The human specie is composed of both male and female and our continued existence requires the mating of these two opposites. But, just as some species require sexual reproduction on the one hand, there are other species that reproduce asexually. Looking at the principles of mathematics, one notes that some numbers are even, devisable by two, whereas, others are odd and cannot be divided by two. It was recently discovered that our very DNA is composed of a double helix. The plant kingdom is divided into dicots and monocots.

Another important dichotomy for humans, at least, is the fact that the body can use both glucose oxidation and fatty acid oxidation as a source for fuel.

Dr. Barry Sears in his book, The Anti-Inflammation Zone, notes that, “…eicossanoids (eye-KAH-sa-noids) control inflammation, and that is becoming recognized as the underlying cause of many, if not all, chronic disease states that now threaten to destroy our health care system”. Many diseases such as arthritis, diabetes, cancer, heart disease, and Alzheimer’s all have a strong inflammatory component. Dr. Sears notes that if we control the inflammation, we can minimize, if not reverse, the symptoms of these chronic diseases.

If that is the case, then we can find “thorn-like” defense mechanisms and examples of “clashes of the opposites” in most, if not all, of nature’s life forms. Speaking of the latter, let’s look at blood transfusions. Doctors found out the hard way that transfusing blood from someone with Type A blood into a patient with Type B blood can cause death.

The Laws of Manu says that the pairs of opposites were ordained by the world-creator. The Ramayana says: “This world must suffer under the pairs of opposites for ever”.

In his book, The No-Grain Diet, Dr. Joseph Mercola notes, “In your body, grains, grain products, starches, and sugars have one thing in common: they rapidly turn to glucose, promote addictive eating habits, and trigger insulin release, all of which contribute to weight gain and other health problems”.

Let’s see how this causes problems. We call ourselves omnivores, meaning that we can eat anything. This says that man can exist on glucose and/or fatty acid metabolism. However, nature expects animal species in general to be either herbivores or carnivores, not both. Different, or, opposite pathways of oxidation is involved, so, it is one or the other.

Until we learned to master fire and invented agriculture, humans, by necessity, were primarily vegetarians – eating what they could chew.

Remember two things. 1) the Yin Yang principle states that one can change into the other, and, 2) the body can use glucose oxidation or fatty acid oxidation for energy.

The following shows that there is a switch (I call it a reversal of the opposites) from glucose to fatty acid metabolism as a result of too many fatty acids in the body.

“Recent findings: Recent studies have concentrated on inhibition of insulin-stimulated glucose uptake by free fatty acids as the primary cause of insulin resistance, particularly in muscle, a major site of insulin-stimulated glucose disposal”, per Internet article entitled, Over expression of muscle lipoprotein lipase and insulin sensitivity, at http://www.co-clinicalnutrition.com/pt/re/conutrition/abstract.000751.. . In general, the more excess body fat you have, the more insulin resistance you have.

According to my theory, Type II diabetes is caused by first, an overabundance of glucose brought on by consumption of grains, grain products, starches and excess sugars. Type II diabetes is a process whereby the body is in the process of switching from glucose oxidation to fatty acid oxidation for energy. Type I diabetes represent a complete switch from glucose to fatty acids as an energy source.

Let’s look at the plant kingdom opposites of monocots and dicots. The cereal grasses such as wheat, barley, oats, rye, corn, etc., are monocots. Cereals such as wheat have a unique form of defense (“thorns”) insuring the balance of nature. Two protein molecules, glutanin and gliadin, combine when chewed by animals or worked over and over as dough is kneaded in the bread-making process. Gluten forms a network that traps air bubbles, primarily from carbon dioxide, created by baking power or yeast giving bread its characteristic texture and air bubbles.

The herbivores that that live on grasses are called ruminants. They are especially equipped to handle grasses and avoid the inherent “thorns”. The ruminants have multiple chambers in their stomachs with the first part of the stomach being the rumen. According to an Internet article entitled, Do cows chew gum?, at http://www.ag.ohio-state.edu/~twig/animals/html/022397.html , “Each new mouthful of food goes directly into the rumen”. In the rumen, microbes partially digest the grasses and then the ruminant regurgitates and chews the cud. Consequently, the ruminants avoid masticating the glutanin and gliadin protein molecules that in turn activate gluten.

Scientists say that blood Group A resulted from the introduction of the agricultural diet. It seems to me that such a low-glucose/high starch (fatty acid) diet, caused the reversal of blood Group B to the opposite blood Group A.

For humans, gluten appears to be the ultimate Trojan horse. The “thorns” – the ability to make dough rise, (gluten) in wheat and other cereals is the special attribute that humans value. In fact, we believe that the more gluten in the flour the better the flour.

“Dairy products, wheat and its close relatives, oats, barley, and rye, have proved to be a major problem in the diets of our patients. There are many possible reasons for cereal grains to become pathogenic”, according to the Celiac.com Internet article, Arthritis and Celiac Disease, posted at http://www.celiac.com/st_prod.html?p_prodid=87 . This article suggests that hypersensitivity mechanisms triggered by grain proteins and this is the likely cause of the illnesses related to the consumption of cereal grains.

So, this is key - the human body which lacks the multiple chambers in the stomach, and, does not chew the cud, becomes hypersensitivity to the presence of the “thorns” found in cereal grains. Let’s see some of what happens.

A wheat gluten mechanism has been studies in rheumatoid arthritis patients. The clinical observation is that wheat ingestion is followed within hours by increased joint swelling and pain. Dr. Barry Sears in his book, The Anti-Inflammation Zone, notes that, “…eicosanoids (eye-KAH-sa-noids) control inflammation, and that is becoming recognized as the underlying cause of many, if not all, chronic disease states that now threaten to destroy our health care system”.

A pair of opposites is evident in the eicosanoids in the body’s cells. One the one hand, we have the pro-inflammatory ones that promote inflammation and tissue destruction, and, on the other hand, we have the anti-inflammatory ones that stop inflammation and promote healing. Dr. Sears notes that if these opposites are out of balance, for instance, if the pro-inflammatory eicosanoids aren’t called back to the barracks, inflammation runs amok and your immune system starts attacking your body. He suggests that we can move from pro-inflammatory eicosanoids toward anti-inflammatory eicosanoids first and foremost by modifying …”what you eat”.

There is another pair of opposites in human anatomy called secretors and non-secretors.

Secretors reverse their Lewis antigens from a+b- to a-b+. Secretors, between 80 and 85 percent of the population, also secrete their blood type antigen in their bodily secretions such as saliva and semen.

So, how does the human body respond to an enemy that it can hardly identify? The answer is that it does what it can to keep the varmint out.

Celiac Disease

Celiac disease is a severe intestinal intolerance to wheat or gluten. People whose body can recognize gluten as the enemy require an absolute wheat/gluten restriction for their entire lives. Their immune systems will go so far as complete destruction the villi, the tiny, fingerlike protrusions, that line the small intestines in an effort to prevent entry of gluten into their bodies. Villi normally allow nutrients from food to be absorbed into the bloodstream. People of blood Type O, having antibodies against both Type A and Type B antigens seem better at identifying gluten containing cereals as the enemy.

The human immune system, having identified the culprit, considers this valuable information and passes it along to offspring. Consequently, celiac disease is a genetic disease. It is also considered an autoimmune disease because the immune system seems to be attacking itself, when, in fact it is attacking the Trojan horse gluten which is the cause of the problem. I think that this is the nature of many, if not all, autoimmune diseases. Autoimmune diseases should be called idiopathic immune diseases.

Dr. Joseph Mercola, author of The No-Grain Diet, says, “I am convinced all blood Type O individuals should not eat wheat. I suspect that most of us would benefit from a similar restriction”.

In a study published in the Lancet (July 17, 1999;354:222-223), researchers in Rome, Italy examined 52 patients with idiopathic cardiomyopathy (heart disease with no known cause) for celiac disease. Three of them had celiac disease, suggesting that prevalence of celiac disease in idiopathic cardiomyopathy patients is increased.

According recent research published in the journal Hematology-Oncology Clinics of North America, “Celiac disease is a risk factor for the development of both adenocarcinoma and T-cell lymphoma of the small intestine. The development of lymphoma accounts for the majority of the increased mortality in celiac disease,” according to P.H.R. Green and al, Columbia University College of Physicians & Surgeons.

It seems to me that in Small Intestinal T-cell Lymphoma the body tries to adapt to the gluten diet. Laboratory diagnosis shows the following partial

morphology.

• There is full thickness replacement of the wall of the intestine by large highly pleomorphic lymphoid cells
• The adjacent mucosa often shows vilous atrophy. There are large number of intra-epithelial lymphocytes that may show cytological atypia

The tumor cells have an abnormal peripheral T-cell phenotype. It is reported that in some cases there is absence of CD4 and CD8 expression.

Again, as the body’s immune system tries to protect us from gluten, it ends up on the short end of the stick - The development of lymphoma accounts for the majority of the increased mortality in celiac disease.

Some people react to gluten in the diet with eating disorders. Anorexia and bulimia are linked to celiac disease and therefore gluten intolerance. Many celiac patients say that they avoid eating for long periods to avoid the inevitable uncomfortable (and even painful) symptoms in the stomach. Many celiacs also automatically vomit after meals in which they have consumed gluten-containing foods or anytime their symptoms are nauseating or painful.

Cystic fibrosis is the most frequent lethal genetic disease of childhood. It affects the lungs, digestive system, sweat glands, and male fertility. CF affects approximately 30,000 children and young adults in the United States and about 3,000 infants are born with CF every year. CF is caused by a deletion (delta-F508) in the so-called CF gene.

The normal role of the CFTR protein is to allow chloride ions to exit the mucus-producing cells. When the chloride ions leave these cells, water follows, thinning the mucus. Two hallmarks of the disease are the secretion of thick mucus and dead white blood cells.

I am speculating that CF is a mutation in the gene due to the presence of gluten in the diet for increased mucus protection.

The defect causing CF cause the lungs and pancreas to secrete thick mucus, blocking passageways and preventing proper function, according to researchers. This action also prevents the digestion of cereals and it protects the intestinal tract from the ravages of gluten. The major contents of mucus are 1) bacteria, 2) the regular contents of mucus, and 3) dead white blood cells, which are present in CF’ers in a concentration about 1,000 larger than in normal people. To me, this indicates that the white blood cells in the CF patient tangle with the “thorns” of cereals.

According to Dr. Peter J. D’Adamo in his book, Live Right For Your Type, non-secretors are more prone to generalized inflammation than secretors, although their immune responses are not as efficient. Evidently, secretors have adapted or otherwise found a way to reduce the inflammatory response generated by “thorns” not only in cereals, but also in other foods such as legumes and beans. It appears as though IgE-mediated food allergy is somewhat avoided by secretors. And, this is not the case for the non-secretors.

The “thorns” in cereals are opposite to what the immune system of human can handle. Our immune system is used to presenting one antigen to helper cells ______________ for help in fighting the enemy. Gluten is composed of two proteins and I assume two antigens. Consequently, our immune system can only attack one-half of the gluten problem.

According to a PubMed article entitled, Different profiles of wheat antigens are recognized by patients suffering from celiac disease and IgE-mediated food allergy, located at http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16…, “Dietary intake of wheat can cause tow distinct immunologically mediated diseases with severe gastrointestinal manifestations, celiac disease (CD) and IgE-mediated food allergy. The pathomechanisms underlying these diseases are different…”. The authors conclude that, “This study thus demonstrates that wheat contains antigens/epitopes which are preferentially recognized by CD patients, whereas others elicit IgE-mediated food allergy.

Chemokines are critical for the inflammatory process in autoimmune diseases such as rheumatoid arthritis (RA). The chemokine receptor-5 (CCR5) mediates chemotaxis by CC-chemokines and is expressed by lymphocytes with the Th1 phenotype and monocyte/macrophages. A 32 bp deletion in the CCR5 (CCR5-delta 32 allele) abolishes receptor expression in homozygotes, while CCR5-delta 32 carriers would express less receptor than wild-type homozygotes.

Non-secretors are more prone to both type I and type 2 diabetes than the secretors are.

Non-secretors have a higher rate of alcoholism over secretors. They are also the group that moderate alcohol intake is most likely to have protective effect.

Non-secretors have an increased prevalence of a variety of so-called autoimmune diseases such as ankylosing spondylitis, reactive arthritis, psoriatic arthropathy, Graves disease, Sjogren’s syndrome, multiple sclerosis, etc.

The human major histocompatibility complex (MHC) maps to the short arm of chromosome 6 and contains the polymorphic HLA genes. These genes are fundamental for the acquired immune response. HLA class I products bind to endogenous antigenic epitopes and present them to CD8+ CTLs, while HLA class II products present exogenous antigenic peptides to CD4+ helper T-cells.

“Numerous diseases are associated with the HLA loci and a number of them are autoimmune diseases. HLA-B27 is associated with the spondyloarthropathies (SpA), including ankylosing spondylitis (AS), Reiter’s syndrome, reactive arthritis, inflammatory bowel disease and psoriatic spondylitis. HLA-B27 is highly associated with AS (98% is positive), whereas the prevalence in other forms of SpA varies between 50-80%. The B27-antigen is present in 8-20% of healthy Caucasians, depending on their geographic distribution, with the highest prevalence being in the northern zones

HIV/AIDS

There are two kinds of helper T cells.

• Th1 – These participate in cell-mediated immunity. They are essential for controlling such intracellular pathogens as viruses and certain bacteria, e.g., Listeria and Mycobacterium tuberculosis (the bacillus that causes tb)
• Th2 – These provide help for B cells and, in so doing, are essential for antibody-mediated immunity. Antibodies are needed to control extra cellular pathogens (which – unlike intracellular parasites – are exposed to antibodies in blood and other body fluids).

Like all T cells, Th cells arise in the thymus.

• When they acquire CD4, they are called pre-Th cells
• When they are presented with both
• An antigen and
• Appropriate cytokines, they begin to proliferate and become activated

It is the nature of the stimulation that determines which path they enter: the path leading to Th1 cells or the path leading to Th2 cells.

The antigen-presenting cells (APCs) are called dendritic cells (DC). They

• Ingest antigen by phagocytosis or pinocytosis
• Degrade it, and
• Present fragments of the antigen at their surface
• Secrete cytokines

There are two kinds of dendritic cell

• DC1 – these are descended from monocytes
• DC2 – these appear to be derived from lymphocytes

Th1 Cells

Th1 cells are produced when DC1-type dendritic cells and pre-Th cells form an immunological synapse in which the dendritic cell

• Presents antigen to the T cell’s receptor for antigen (TCR);
• Secretes interleukin 12 (IL-12)

The paracine stimulation by IL-12 activates (through JAK-STAT pathways) the Th1 cells to secrete their own lymphokines:

• Tumor-necrosis factor-beta (TNF-B) (also known as lymphotoxin) and
• Interferon-gamma (IFN-y)

These

• Stimulate macrophages to kill the bacteria they have engulfed;
• Recruit other leukocytes to the site producing inflammation

Th2 Cells

Th2 cells are produced when DC2-type dendritic cells present antigen to the T cell’s receptor for antigen (TCR) and, presumably, one or more paracrine stimulants. The identity of the cytokine(s) is still uncertain

The major lymphokines secreted by Th2 cells are

• Interleukin 4 (IL-4). This
• Stimulates class-switching in B cells and promotes their synthesis of IgE antibodies
• Acts as a positive-feedback device promoting more pre-Th cells to enter the Th2 pathway
• Blocks the IFN-y receptors from entering the immunological synapse on pre-Th cells thus inhibiting them from entering the Th1 path
• Interleukin 5 (IL-5). Attracts and activates eosinophils
• Interleukin 10 (IL-10). Inhibits IL-12 production by DCs thus inhibiting pre-Th cells from entering the Th1 pathway
• Interleukin 13 (IL-13). This also promotes the synthesis of IgE antibodies

The following info was taken from the Internet article entitled Helper T Cells located at http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/T/Th1_Th2.html .

A Th1 response inhibits the Th2 path in two ways:

IFN-y and IL-12 inhibit the formation of Th2 cells;

Ifn-y also inhibits class switching in B cells

A Th2 response inhibits the Th1 path:

IL-4 and IL-10 suppress Th1 formation

Negative feedback of Th1 and Th2 cell formation

There is evidence that late in the immune response, negative feedback mechanisms come into play to dampen the response.

IL-4 kills the precursors of the DC2 cells (by apoptosis) thus inhibiting the Th2 path and further production of IL-4

IFN-y may eventually turn off the Th1 response that produced it.

Th1 and Th2 cells have different chemokine receptors.

Chemokines are cytokines that are chemotactic for (attract) leukocytes. Because they are chemotactic cytokines, chemokines are designated by the initials CC.

Chemokines bind to receptors on the responding leukocyte. The receptors are transmembrane proteins with the chemokine-binding site exposed at the surface of the plasma membrane. Chemokine receptors are designated CCR.

Th1 cells and Th2 cells have opposite functions.

Th1 cells express the chemokine receptor CCR5 (but not CCR3).

Th2 cells express the chemokine receptor CCR3 (but not CCR5).

CCR3

One chemokine that binds to CCR3 is called eotaxin. It is secreted by epithelial cells and phagocytic cells in regions where allergic reactions are occurring.

CCR3 is found on

· Th2 cells

· Eosinophils

· Basophils

All cells implicated in allergic responses (e.g., asthma).

CCR5

CCR5 is found on

• Th1 cells, especially those in the lymphoid tissue of the intestine
• Macrophages

CCR5 also acts – along with the CD4 molecule – as a co-receptor for HIV-l, the retrovirus that causes AIDS. This fact may explain

· Why destruction of the lymphoid tissue of the intestine occurs soon after HIV infection;

· Why certain HIV-infected men

· With inherited mutations in CCR5 or

· Who produce high levels of the natural ligand for CCR5 (a chemokine designated CCL3L1). CCL3L1 presumably competes with HIV for access to CCR5.

· Can tolerate their infection for long periods without progressing to a full-blown case of AIDS;

· The collapse of cell-mediated immunity in the late stages of AIDS.

End

CCR5 cytokine levels correlate with disease activity of Wegener’s Granulomatosis patients.

Chemokines are critical for the inflammatory process in autoimmune diseases such as rheumatoid arthritis (RA). The chemokine receptor-5 (CCR5) mediates chemotaxis by CC-chemokines and is expressed by lymphocytes with the Th1 phenotype and monocyte/macrophages. A 32 bp deletion in the CCR5 (CCR5-delta 32 allele) abolishes receptor expression in homozygotes, while CCR5-delta 32 carriers would express less receptor than wild-type homozygotes. This polymorphism is related to the resistance to HIV-1 infection and progression towards AIDS. We hypothesized that the CCR5-delta 32 allele may modulate the severity of disease in RA. A total of 160 RA-patients (71 and 89 with severe and non-severe phenotypes, respectively) and 500 healthy individuals from the same Caucasian population (Asturias, northern Spain) were genotyped. Carriers of the CCR5-delta 32 allele were at a significantly higher frequency (P – 0.012) in non-severe compared to severe patients (17$ vs. 4%). Our results suggest that the CCR5-delta 32 polymorphism is a genetic marker related to the severity of RA.

As stated earlier wheat contains antigens/epitopes, which are preferentially recognized by CD patients, whereas others elicit IgE-mediated food allergy. In other words, the human immune system is incapable of recognizing the “thorns” in the gluten proteins. Also, as a problem of the opposites, the human immune system is incapable of defending against the “thorns” in cereals.

“An elevated IgE level and increased production of T(H2) cytokines are factors associated with poor prognosis in HIV infection”, per PubMed article entitled, Cytokine profile of a long-term pediatric HIV survivor with hyper-IgE syndrome and a normal CD4 T-cell count, at http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=20.. .

I have read that the DNA double-helix of monocots is different from the one of humans and dicots. Apparently, one strain of the DNA of monocots is the same as ours and one is different. Gluten and other monocots present “thorns” that our immune system cannot handle and are, therefore, likely responsible.

HIV Is Another Way of Saying Eurica

Breastfeeding passes on crucial antibodies to infants that protect them against allergies. It is reported that half of the children with HIV in sub-Saharan Africa today were infected with the disease through breast milk from their HIV-positive mothers. Could the transmission of HIV be a way of one human informing another that the enemy has been identified and what it looks like?

Could HIV/Aids result from humans finally becoming able to recognize the villain in cereal grains and stimulating the body to begin a war against an enemy (gluten) that it cannot win? Or, is it that late in the immune response against HIV, a negative feedback mechanisms come into play to dampen a Th response?

It is estimated that 59% of LGBT youth smoke, whereas the prevalence rate in the general youth population is only 37%.

It is reported that cocaine and amphetamines are so addictive because they increase dopamine. However, Dr. Jack B. Stein, Ph.D., deputy director, Office of Science Policy and Communications, National Institute on Drug Abuse (NIDA) has demonstrated changes in the brain with photographic evidence from PET-scans of methamphetamine abusers that show a depletion of dopamine. (L.A. Gay & Lesbian Center – Report From The Third Lesbian, Gay, Bisexual and Transgender Health Roundtable – June 6 – 7, 2002). Maybe, drugs such as cocaine, crack cocaine, crystal, Ecstasy and other club drugs should be classified as depressants instead of stimulants.

Of all stimulants, users of crystal methamphetamine take fewer years to enter treatment; the average use is 3.7 years. It is reported that 91% of crystal users are HIV-infected, whereas only some 33% of users of other stimulants are infected. Sexual activity occurs in 91% of crystal users and in 56% of other stimulant users. Crystal users are almost three times more likely to consider recent sexual behaviors as compulsive (64%) compared to other stimulant users (22%), and to have more sexual partners in the last 30 days (crystal users, 5.5 partners; users of other stimulants, 2.1 partners). Crystal users have more than three times the number of sexual partners (19) in the previous six months than other stimulant users (6). Users of crystal describe it as pushing sexual extremes, pushing sexual intensity, prolonging sexuality and increasing thoughts about sex.

L.A. Gay & Lesbian Center – Report From The Third Lesbian, Gay, Bisexual and Transgender Health Roundtable – June 6 – 7, 2002.

Depression and chronic hopelessness is frequently seen with those in long-term substance abuse treatment facilities and those living with HIV, as well as their care providers. By 2010 depression will be the number one mental health diagnosis for LGBT people.

Gay men are more likely to be extroverted, use alcohol, and, be single or in short-term relationships according to Internet article Introduction to Gay Male Domestic Violence at http://www.psychpage.com/gay/library/gay_lesbian_violence/dv_gay…

Vioxx

Anti-inflammatory drugs work to stop the production or overproduction of pro-inflammatory eicosanoids.

ADHD

The hyperactivity in ADHD could result from over stimulation of the sympathetic branch of the nervous system by “thorns” in the diet. The sympathetic nervous system is designed to take action on a moment’s notice. It does not wait around for thinking. It is more reactive.

Carl Jung wrote about the opposite functions of Thinking versus Sensing. When the body is constantly in a reaction mode the senses become the dominant function.

The body responds to these “thorns” by activating the excitatory neurotransmitter dopamine.

“When your body is in a constant state of silent inflammation, it reacts by having your adrenal glands pump out high amounts of cortisol, the primary anti-inflammatory hormone you have to shut down excess inflammation”, per Dr. Sears in his book, The Anti-Inflammation Zone.

Over time, the body adapts by gearing up for an intense inflammatory response and this propensity is passed on to our offspring for their benefit.

Marti Olsen Laney, Psy.D., author of the book, The Introvert Advantage, notes that, “Not only does introverts’ and extroverts’ blood travel on separate pathways, each pathway requires a different neurotransmitter”. On their more dominant pathway, Extroverts use the neurotransmitter activated by dopamine. On their dominant pathway, Introverts use the opposite neurotransmitter activated by acetylcholine. According to Dr. Laney, acetylcholine “affects attention and learning (especially perceptual learning, influences the ability to sustain a calm, alert feeling and to utilize long-term memory, and activates voluntary movement. It stimulates a good feeling when thinking and feeling.” Acetylcholine is quite involved in the brain. It is associated with sleep and dream states and a deficiency of acetylcholine is linked to Alzheimer’s disease. Estrogen is supposed to prevent a decline in this neurotransmitter.

The neurotransmitter dopamine is most closely identified with movement, alert states, attention and learning. The level of dopamine in the body is increased by the release of adrenaline.

It is reported that cocaine and amphetamines are so addictive because they increase dopamine. However, Dr. Jack B. Stein, Ph.D., deputy director, Office of Science Policy and Communications, National Institute on Drug Abuse (NIDA) has demonstrated changes in the brain with photographic evidence from PET-scans of methamphetamine abusers that show a depletion of dopamine. (L.A. Gay & Lesbian Center – Report From The Third Lesbian, Gay, Bisexual and Transgender Health Roundtable – June 6 – 7, 2002). Maybe, drugs such as cocaine, crack cocaine, crystal, Ecstasy and other club drugs should be classified as depressants instead of stimulants.

Over stimulation of dopamine eventually causes lower sensitivity.

Extroverts are more sensory orientated. The area of the brain where their blood flows is where visual, auditory, touch, and taste (excluding smell) occur.

Dr. Laney notes that Introverts are highly sensitive to dopamine and that too much will leave them over stimulated. Since our kids are hyper I would assume that they of usually of the Introvert persuasion.

ALS

Acetylcholine paralyzes us (disengages voluntary movement) when REM sleep is switched on initiating dreaming. Dr. Laney quotes Ronald Kotulak who writes in his book Inside the Brain, “Acetylcholine is the oil that makes the memory machine function. When it dries up the machine freezes.”

One patient with ALS indicated that he was allergic to MSG and that whenever he would drink beer his ALS symptoms would worsen. MSG and beer come from cereals.

According to an Internet article entitled, “My Ideas As To The Cause Of ALS” at http://members.aol.com/pganzel/my.html , Peter Ganzel, an ALS patient, interviewed others afflicted with ALS along with his own insights and created a profile of a typical ALS patient. Three things on the profile are:

Athletic

Heavy dairy consumption

Tremendous stress

It appears to me that there is an attempted switch of the primary neurotransmitters in the brain – from acetylcholine to dopamine. Up until around age 2, the dominant neurotransmitter in the brain is dopamine then it switches to acetylcholine. The heavy dairy consumption may cause the body to attempt to revert back to the dopamine pathway.

Introvert vs. Extravert

Dr. Laney believes that the basic foundations Introversion and Extroversion are determined by whichever branch of the autonomic nervous system is primarily activated. Parasympathetic activation equates to Introversion and sympathetic activation equals Extroversion.

I think that the orientation of the Th1 and Th2 response may be the determining factor as to which neurotransmitter and particular branch of the nervous system is activated. Th1 is focused on the internal functioning of the cells, whereas, Th2 is focused on the external concerns of the cells.

Gay men are more likely to be extroverted, use alcohol, and, be single or in short-term relationships according to Internet article Introduction to Gay Male Domestic Violence at http://www.psychpage.com/gay/library/gay_lesbian_violence/dv_gay…

Our children’s bodies run primarily on an Extraverted basis until they are around two years old.

Multiple Sclerosis

It is reported that in individuals with MS, there is evidence that specific white blood cells are primed to recognize and launch attacks against apparently normal components of the nervous system.

The body attacks itself through a process called apoptosis – the necessary death of cells. This is a form of cell death that is necessary to make way for new cells and to remove cells whose DNA has been damaged to the point at which cancerous change is liable to occur.

The fact that it has become clear since the mid-1990’s that individuals without MS also have T cells that react against myelin is additional evidence that MS could be a reaction of the body against the amino acid glutamic acid.

Health Disparities

Approximately one in every 25 Americans of northern-European descent is a carrier of the mutated CF gene, but, only one in 17,000 African Americans and one in 30,000 Asian Americans are carriers.

Natural selection would dictate that such harmful consequences of a mutation would dictate its demise fairly soon. Some evolutionists say that such a high mortality of CF would quickly lead to loss of the mutated gene from the population. However, natural selection is not at play here.

Too Much – The Great Tsunami

Since the advent of farming, the agricultural diet has provided too much energy to the body. Consequently, enzymes have had to tone-down or decrease in activity. Caucasians exhibit this in the enzyme activities that provide skin color, eye color and hair. The ability to taste food has decreased creating a need for MSG. Many people have a reduced ability to recognize several nutrients such as PROP.

G6PD in some 400 million people reflect a decrease in these people’s ability to use energy.

Cystic Fibrosis causes a decrease in the ability to thin mucus.

Why Do Roses Have Thorns

A New Theory of Disease

My Theory In a Nutshell 12/14/05

An important dichotomy for humans is the fact that the body can use either glucose oxidation or fatty acid oxidation as a source for fuel. In the presence of glucose in the diet from vegetables and fruits, as designed, the body works wonderfully. The lack of sufficient glucose in the diet triggers the body to fall back, default, or, in other words, go to the opposite energy source – fatty acids, for survival. However, this energy pathway results in destructive metabolism, but, helps insure the continuation of the specie.

Part of our problem is that there are “thorns”(a euphemism for lectins) in wheat and other seeds, and, vegetables for that matter, that activate our immune system as these “thorns” represent a danger to our well-being. The cereals utilize gluten as their “thorns”. Cereals such as wheat have a unique form of defense (“thorns”) insuring the balance of nature. Two protein molecules, glutanin and gliadin, combine when chewed by animals or worked over and over as dough is kneaded in the bread-making process. For the cereals, this is a great secret weapon. Most of our immune systems cannot detect gluten as being an enemy. Then, once it is targeted by the immune system, as in celiac disease, it is recognized as the formidable foe that it is. Gluten represents an opposite as to what our immune system can defend us against. In my opinion, that is why grass herbivores have multiple chambers in the stomach and chew the cud or masticate the grains after the “thorns” have been disabled or neutralized by microorganisms in the rumen.

Gluten forms a network that traps air bubbles, primarily from carbon dioxide, created by baking power or yeast giving bread its characteristic texture and air bubbles. For humans, gluten appears to be the ultimate Trojan horse. The “thorns” – the ability to make dough rise, (gluten) in wheat and other cereals is the special attribute of wheat that humans value in bread making. In fact, we believe that the more gluten in the flour the better the flour.

As the ratio of starch to glucose increase, the more there is of a tendency to switch or migrate to the opposite form of energy. The complete migration to fatty acids oxidation is reflected in Type 1 diabetes. According to Diabetes – UK, prior to the advent of insulin, Type 1 diabetes were placed on a milk diet, which allowed them to live up to two years. Type 2 diabetes, in my opinion, represents a “switch to the opposite” in progress. As the body migrates from glucose to fatty acids, the body’s cells become less sensitive to insulin. In fact, the beta cells of the pancreas switch function from the production of insulin to the production of amylin as first noted by Eugene L. Opie and Leonid Sobelev somewhere around 1902. According to the book, The Diabetic Male’s Essential Guide to Living Well, by Joseph Juliano, M.D., Opie and Sobelev identified that change in function of the beta cells resulted in diabetes.

In order to fight cancer, one needs to determine just what cancer is. Tumors represent a way of altering or adapting the functions of the body’s organs and tissues to a different environment. Cancer results when the body cannot control the tumor or adaptation process, in my opinion, sometimes due to the influence of peptides from gluten.

As the ratio of starch to glucose increases, there is increased pressure on the body to make adjustments. Linus Pauling, the chemist and biologist that is among the few people awarded two Nobel Prizes, advocated that it was the lack of vitamin C in the diet that caused cancer. He was partially correct. It is the lack of a glucose-providing, vitamin C providing diet that naturally comes with the consumption of fruits and vegetables that cause cancer. Keep in mind, humans do not manufacture vitamin C, therefore, it must come from the diet. This vegetarian diet is tuned to provide all of the requisite nutrients in their correct ratios from a vegetarian diet. For instance, prior to the advent of farming, the Neolithic man spent most of his days eating herbaceous materials. Of course, there were some editable seeds during the seed-bearing part of the year. It is easy to surmise that they didn’t get a lot of energy from such a diet. However, that was the status quo until the advent of farming and domestication of animals. Subsequently, man body has had to adjust to excess nutrients in the diet. For example, the body needs iron for hemoglobin. The body absorbs 10 times more iron from meat than it does from fruits and vegetables. Consequently, the body needs to make adaptations. In many cases, these changes are made by mutations of genes and many of these mutations result in tumors, some of which go out of control and form cancer. This is to be expected when the “opposites of the body” are out of control.

Consumption of grains and seeds cause a shift in the opposites of cholesterol. HDL decreases and LDL increases. According to LipoScience, Inc., it is the amount and the size of the particles in LDL cholesterol and triglycerides that is indicative of coronary heart disease risks. Let’s observe two pairs of opposites in play – size and quantity.

Large size particles, whether in HDL, LDL and/or triglycerides represent a lower CHD risk. On the other hand, small size particles in HDL, LDL, and/or triglycerides (VLDL) are indicative of greater risks. As far as quantity of particles is concerned, a smaller number of them equals smaller risk, and, more of them increases the risk of CHD. Although these particles are too small to be analyzed these particles can be expected to contain peptides of gluten and other plant lectins (“thorns). The LDL is protective in surrounding the “bad guys” in fat, thereby isolating them from necessary water. Consequently, considering the circumstances causing “thorns” in the triglycerides, hypercholesterolemia, as provided by the immune system, is protective.

As indicated earlier, the “thorns” in cereals represent an enemy that our immune system was not designed to handle. Arthritis and, eventually, cancer, Alzheimer’s and AIDS are likely to result.

Niacin (nicotinic acid) has the ability to reduce small LDL particles by some 30 to 50 percent according to LipoScience, Inc. Is this the reason that people smoke, especially after eating? I think that the answer is definitely yes.

Drugs such as Vioxx that affect the COX enzymes have the effect of disarming the immune system response, and, in essence, leaving the body unprotected against the “thorns” of gluten and other seeds.

Pythagoras, the Greek philosopher and mathematician, said, “Don’t eat fava beans”. Fava beans were the sole representative of beandom in Europe until the discovery of America. Pythagoras did not say why one should not eat such beans, however, he was aware that there were “thorns” in those beans that could adversely affect the human body.

Favism or Glucose-6-phosphate dehydrogenase deficiency (G6PD) is an inherited X-linked recessive trait (Lamb) that affects over 400 million people throughout the world, and, it is the most common enzymopathy in the world (King and Stansfield). To put it another way, G6PD deficiency is the most common enzyme deficiency in the world.