Cause of Alzheimer's & Breast & Prostate Cancers

Floyd’s Herbivore Feeding Deterrents (Thorns) Hypothesis on Cause of Alzheimer’s Disease And Others Diseases Paul Ewald, professor of biology and author of the book, Plague Time, The New Germ Theory of Disease, wrote, “Cancer, heart attacks, stroke, Alzheimer’s disease, and infertility are like the acts of an anonymous vandal”. In his book, Excitotoxins, The Taste that Kills, Russell L. Blaylock, M.D. notes that a multitude of seemingly unrelated diseases, such as strokes, heart attacks, arthritis, brain injury, migraine headaches, and cancer are associated with excitotoxins such as glutamate, calcium and cell death. Dr. Blaylock writes, “It appears that several of the excitotoxins, including glutamate and aspartate, work by opening calcium channels, at least on certain subtypes of receptors”. My theory or hypothesis is that the influx of calcium into the cell is not the cause of the cell death, but is in response to the threat of toxicity posed by that “anonymous vandal” that Paul Ewald writes about. This so-called “vandal” or “vandals”, in my opinion, are agents of Nature that are there to enforce Nature’s balance. Nature employes the use of phenolic compounds (I call them “thorns”) in plants as feeding deterrents to herbivores. These compounds can be grouped in three major groups: alkaloids, terpenoids, and phenolic compounds (mostly phenylpropanoids). The oxidation of these thorns creates a significant risk for our bodies by the release of excessive free radicals. Alkaloids (poisons), are synthesized principally from amino acids. These nitrogen-containing compounds protect plants from a variety of herbivorous animals, and many possess pharmacologically important activity. Our immune system’s defenses were not designed to overcome these deterrents over the long run. Consequently, as we learn to avoid them, or reduce the activity of our enzymes that oxidize them, the better off we are at consuming those plants. Dr. Blaylock lists the amino acids glutamate, aspartate and cysteine as excitotoxins that are found in nature. Phenolic compounds are widely distributed in the plant kingdom. Wheat appears to be well protected by Nature as it is quite high in alkaloids. Dr. Blaylock wrote, under the topic of, A Cascade of Destruction: The Free Radicals, that, “Once this cascade of destruction is triggered by the influx of calcium, the whole process proceeds with the explosiveness of a nuclear chain reaction”. I think that the process is initiated when our enzymes act on the inhibitors. I see this as nature’s way of enforcing its Balance of Nature by using agents such as “thorns” or inhibitors. Others have said that the redox process inside the cell is likened to a severe thunderstorm. When our bodies try to oxidize the “thorns” they become emboldened – just the opposite of what you would expect. Many of nature’s inhibitors come into the body via the diet and end up in VLDL cholesterol. The cholesterol remnants apparently containing these “thorns” are eventually transferred to LDL cholesterol. APOE is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. As herbivores, including man, attempt to metabolize these “thorns” in the lipoproteins, excessive damage to the tissues ensue. Consequently, as a process of adaptation to the “thorns” in the diet, the body has mutated and produced two additional forms or alleles of the APO-E gene. Notice the difference in the different gene products. The APO-E2 does not bind tightly to its cell surface receptor and the “thorns” have difficulty getting into the cells. However, a consequence of the APO-E2 mutation is the build-up is a terminal disease called hyperlipoproteinemia. APO-E3 is the most common form of the allele and is probably the wild-type. That leaves APO-E4. Let’s see what kind of a change it offers in response to the “toxins” in the triglyceride-rich lipoprotein constituents. APO-E4 can bind to its receptor but binds to cholesterol to a lesser degree than APO-E3. As a result, people with APO-E4 allele often have high levels of cholesterol in their blood. So, the alternate APO-E alleles E2 and E4 result in less affinity of either the receptor or cholesterol itself. This lesser affinity for cholesterol on the part of APO-E4 is largely responsible for the familial or late onset form of Alzheimer’s disease.